Health Science – University of Bosaso

THE UNIVERSITY OF BOSASO COMMEMORATES THE WORLD DIABETES DAY

Ahmed — Sat, 16 Nov 2024 13:36:47 +0000

The University of Bosaso is pleased to share that it recently hosted a significant event at its main campus to commemorate World Diabetes Day. This annual global observance aims to raise awareness about diabetes and the importance of preventive measures, early diagnosis, and effective management. The ceremony at the University highlighted the institution’s dedication to supporting health initiatives and fostering awareness within the community.

The event brought together a diverse group of attendees, including the University administration, faculty members, healthcare professionals, and representatives from the Bosaso District Council. Their collective presence underscored the importance of community cooperation in addressing public health challenges.

During the ceremony, officials and notable speakers took the stage to discuss the impact of diabetes on individuals and communities. They emphasized the critical need for education about managing the condition and guided how to offer practical support for those living with diabetes. Their speeches highlighted the ongoing challenges associated with the disease, including misconceptions and the lack of resources in some areas.

The event served as a platform for education and a reminder of the importance of empathy and understanding toward individuals affected by diabetes. It concluded with discussions on potential strategies for fostering healthier lifestyles and the role that institutions like Bosaso University can play in promoting public health awareness and collaborative initiatives.

The University of Bosaso remains committed to actively participating in public health education and reinforcing partnerships with local and regional entities. Through such events, the University aims to build a knowledgeable and health-conscious community that prioritizes well-being and mutual support.

CCND1 as a Prognostic and Diagnostic Biomarker and the Impact of Its Epigenetic Alterations on Cancer Survival

Ahmed — Wed, 30 Oct 2024 06:34:16 +0000

Abstract

Background: Cyclin D1 (CCND1) plays a crucial role in cell cycle regulation and has been implicated in various cancers. As is well known, cancer is caused by the accumulation of detrimental variations in the genome. In this study, we shed light on the role of CCND1 in the diagnosis and progression of cancer and aimed to provide a comprehensive analysis of CCND1 across multiple cancer types, focusing on its expression, clinical correlations, DNA methylation status, prognostic implications, genetic alterations, and immune infiltration. Methods: Gene expression analysis of CCND1 was conducted across 33 cancer types using the TIMER, GEPIA, and UALCAN databases. Clinical parameters were investigated to assess their correlations with CCND1 expression. Methylation analysis was performed using the UALCAN and GSCA databases to investigate the relationship between CCND1 promoter methylation and gene expression and their association with survival. Immune infiltration and survival analyses were performed to explore the prognostic implications of CCND1 expression in various cancers. Statistical tests, such as the Cox proportional hazards model and the Kaplan-Meier analysis, were used to assess survival outcomes. Additionally, genetic alteration analysis was performed using the cBioPortal database to examine the prevalence and types of CCND1 alterations across different cancer types. Results: CCND1 expression was significantly elevated in 13 cancers compared to normal tissues, with distinct patterns observed across different cancer types. It is highly expressed in BLCA, CHOL, COAD, ESCA, GBM, HNSC, KIRC, PAAD, RRAD, READ, STAD, THCA, and UCEC. The investigation of clinical parameters revealed associations between CCND1 expression and factors such as age, gender, race, and cancer stage. The methylation analysis highlighted hypomethylation of CCND1 across the 13 selected cancer types. The survival analysis identified both favorable and unfavorable prognostic implications of CCND1 expression in different cancers and revealed that a high expression of CCND1 was associated with a poor prognosis in HNSC and PAAD, while a high expression of CCND1 was associated with a good prognosis in KIRC, STAD, THCA, and UCEC. In the immune infiltration analysis of various cancers, many statistically significant correlations were observed between the immune cell types and tumor purity. For example, in BLCA, neutrophils and dendritic cells showed statistically significant positive correlations and a negative correlation with macrophages. While in CHOL patients, none of the immune cell types showed a significant correlation. Similar statistical significance was observed in other cancer types, such as COAD, HNSC, GBM, KIRC, PAAD, PRAD, READ, and STAD, with different immune cell types. The genetic alteration analysis revealed that amplification was the predominant genetic alteration type in CCND1, with specific patterns observed in different cancer types. Conclusion: The findings of this study provide valuable insights into the role of CCND1 in cancer diagnosis and progression, and its potential for targeted therapies. CCND1 could be used as a potential diagnostic biomarker for the COAD, ESCA, KIRC, READ, STAD, and THCA stages. Furthermore, CCND1 could be used as a potential prognostic biomarker for HNSC, KIRC, and PAAD. Also, the correlation between CCND1 methylation and expression could be used as a potential diagnostic and prognostic biomarker for ESCA, HNSC, and STAD.

Download Full Journal

PREVALENCE OF GASTRIC INFECTION AMONG THE POPULATION OF PUNTLAND STATE OF SOMALIA

Ahmed — Tue, 29 Oct 2024 07:36:54 +0000

Abstract

Infections that affect the stomach or intestines are referred to as gastrointestinal infections (GI) and are considered to be a common global health problem. Low income and middle-income countries report higher mortality rates due to GI and this is especially experienced among children aged five years and below. Somalia as a country is at a crossroads of poverty, conflict and environmental changes that are having detrimental effects on the population. A current study on the prevalence of gastric infections for the population within Bosaso is therefore required to understand the prevalence of the disease and the current measures used in order to come up with effective preventative and treatment measures. The findings of the study indicate a high prevalence of gastric infection within the community as 77% of the respondents had gone to hospital for treatment, with symptoms reported including loss of appetite, pain in the upper abdomen under the ribs, vomiting, weight loss and nausea or indigestion were the most common symptoms. Prevention and treatment should therefore focus on these common symptoms. The current treatments used by the majority of the respondents that were considered effective include antibiotics, oral rehydration drinks, anti-vomiting or antidiarrhea drugs and intravenous fluid replacement. The findings of the study also indicate that the foods that should be reduced in order to prevent gastric infections include salty foods, juice and sweet foods while bottled juice, soda and black tea or coffee were drinks that were found to trigger gastric infections. Most of these foods are eaten during breakfast and lunch and are mostly homemade. Measures to improve homemade food handling and cooking should be used to reduce the prevalence of gastric infection among the community since the majority of the people do not miss these meals.

Comparative Evaluation on Antimicrobial Activity of Azadirachta indica (Neem) Leaf Extract and Commercial Toothpaste (Spearmint), Against Clinical Isolates Dental Caries Bacteria in Sudan

Ahmed — Sat, 26 Oct 2024 08:42:06 +0000

Abstract

Azadirachta indica is an evergreen, temperature tolerant, flowering plant distributed in India and other continents of the world. It is among medicinal plants with amultipurpose and multiple health benefits both traditional and pharmaceutical industries. Objectives: To identify bacteria species that cause carious teeth, to verify and compare the activity of A. indica extract and commercial toothpastes against thirty clinical pathogenic bacteria. Material and Methods: thirty bacterial test strains: Streptococcus spp, Lactobacillus acidophilus, Staphylococcus aureus, pseudomonas aeruginosa and Proteus vulgaris was carried out in the study. Ethanolic extract of A. indica leaves and aqueous commercial toothpaste were prepared at varying concentrations which were applied on inoculated plates of Muller Hinton agar (MHA) using well diffusion method. Standardized discs of the synthetic antibiotics: ciprofloxacin and novobiocin were also applied on inoculated plates of (MHA). Results: A. indica leaf extract showed moderate antimicrobial activity against all bacterial species studied tested except Pseudomonas aeruginosa. It showed maximum inhibition against Lactobacillus acidophilus at 12.5 mg/ml concentration, when compared with commercial toothpaste (p = 0.004). Conclusion: A. indica leaves possess good antibacterial activity confirms the great potential of bioactive compounds and is useful for rationalizing the use of this plant in primary health care.